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Inadequate/Considerable Metabolizers, CYP2D6 The development in the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Around seven% with the population has lessened action of the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme process. These folks are “inadequate metabolizers” of debrisoquine, dextromethorphan and tric